Why the study?
Does perioperative atenolol administration prevent cardiac death compared to placebo, or is the observed effect due to sudden withdrawal of beta-blockers in the placebo group?
Does perioperative atenolol administration prevent cardiac death compared to placebo, or is the observed effect due to sudden withdrawal of beta-blockers in the placebo group?
Answers are grounded in this paper and cite their sources.
This letter highlights the potential confounding effect of sudden beta-blocker withdrawal in perioperative trials evaluating beta-blocker initiation.
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Diegeler et al. (1997) conducted a letter in Perioperative ischemia. Atenolol vs. Placebo was evaluated on Deaths from cardiac causes.
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