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Molecular weight determination by plasma desorption (PD) mass spectrometry has been used in the different stages of protein sequence determination. It has been found to be a very valuable addition to the traditional techniques. For analysis in biotechnological development and production PD mass spectrometry meets the requirements for speed, precision and mass range. The amount of information can be increased by combining 'wet' biochemical procedures with analysis by PD mass spectrometry.
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Roepstorff et al. (1988) studied this question.
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