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There appears to be no distinct HLA association with central nervous system involvement in poliomyelitis.
In 1984 to 1985 an outbreak of poliomyelitis was found after a 20-year free period in Finland. The 10 patients with central nervous system disease were studied for HLA antigens. Additionally, two families with two and four affected siblings from the previous outbreak were analysed. The affection of the central nervous system seems not to depend on HLA-associated genetic factors.
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Kinnunen et al. (1986) studied this question.
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