What does this research mean for the field?

A nationwide oral poliovirus vaccination campaign successfully eliminated the circulation of the epidemic wild-type serotype 3 poliovirus in Finland, as demonstrated by the absence of wild-type strains in sewage water surveillance during a 12-month follow-up. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the spread and subsequent elimination of wild-type serotype 3 poliovirus in sewage water before, during, and after a nationwide oral poliovirus vaccination campaign.

February 1, 1988Applied and Environmental MicrobiologyOpen Access

Viruses in sewage waters during and after a poliomyelitis outbreak and subsequent nationwide oral poliovirus vaccination campaign in Finland

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Why the study?

Does a nationwide oral poliovirus vaccination campaign eliminate wild-type poliovirus circulation as measured by sewage water surveillance?

Population

Sewage water specimens from 13 locations in the greater Helsinki district and 13 other cities or towns in…

Comparison

Nationwide oral poliovirus vaccination campaign vs Pre-vaccination campaign period

Design

Other

Follow-up

12 months

Authors

TPTuija PöyryUniversity of Cambridge MSMirja StenvikInstitute for Molecular Medicine Finland THT HoviInstitute for Molecular Medicine Finland

Discussion

Member takes

Implication

Supports sewage surveillance for polio elimination monitoring; leaves open generalizability without prospective validation.

Key Points

To evaluate the spread and subsequent elimination of wild-type serotype 3 poliovirus in sewage water before, during, and after a nationwide oral poliovirus vaccination campaign.
Monitored wastewater across 13 locations in the greater Helsinki district and 13 other nationwide municipalities during the 1984–1985 outbreak.
Conducted a 12-month post-campaign environmental follow-up analyzing 93 sewage specimens for enteroviruses and poliovirus serotypes, testing isolates for temperature sensitivity to distinguish vaccine-derived from wild strains.
Following the oral vaccination campaign, poliovirus serotypes 2 and 3 were isolated from sewage for up to 2 months, whereas serotype 1 cleared more rapidly, with all isolates exhibiting temperature sensitivity characteristic of vaccine strains.
During the 12-month follow-up through the subsequent expected polio season, 72 of 93 specimens were virus-positive, yielding multiple enteroviruses and five vaccine-related poliovirus strains, but zero wild-type polioviruses.

Structured PICO

Does a nationwide oral poliovirus vaccination campaign eliminate wild-type poliovirus circulation as measured by sewage water surveillance?

Population

Sewage water specimens from 13 locations in the greater Helsinki district and 13 other cities or towns in Finland

Intervention

Nationwide oral poliovirus vaccination campaign

Comparator

Pre-vaccination campaign period (during the 1984-1985 outbreak)

Outcome

Presence of wild-type and vaccine-related polioviruses in sewage waters

Environmental surveillance of sewage waters confirmed the success of a nationwide oral poliovirus vaccination campaign in eliminating wild-type poliovirus circulation.

Cite This Study

Pöyry et al. (1988) studied this question.

synapsesocial.com/papers/6a1d2d40ba3016ff712f34c8 https://doi.org/10.1128/aem.54.2.371-374.1988

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Viruses in sewage waters during and after a poliomyelitis outbreak and subsequent nationwide oral poliovirus vaccination campaign in Finland

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Viruses in sewage waters during and after a poliomyelitis outbreak and subsequent nationwide oral poliovirus vaccination campaign in Finland

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider