Key result
Enterovirus 68 was detected in the serum of 12 (43%) of 28 pediatric pneumonia patients with EV68-positive nasopharyngeal specimens, suggesting the virus can cause viremia.
Why the study?
Can enterovirus 68 be detected in the serum of pediatric patients with EV68-positive pneumonia?
Observational (n=28)
Can enterovirus 68 be detected in the serum of pediatric patients with EV68-positive pneumonia?
Enterovirus 68 can cause viremia in pediatric pneumonia patients, suggesting a potential mechanism for systemic manifestations.
EV68 viremia may occur in pediatric pneumonia; hypothesis-generating for systemic spread and requires prospective validation.
Enterovirus 68 (EV68) infection occasionally manifests with fatal outcomes. However, detection of EV68 in serum and its clinical outcomes are yet to be determined. In this study, we retrospectively tested stored serum samples collected from pediatric pneumonia patients whose nasopharyngeal specimens were positive for EV68. Of total 28 nasopharyngeal sample-positive patients, EV68 was detected in serum samples among 12 (43%) patients aged between 1 and 4 years. Our results suggest that EV68 can cause viremia by which the virus may exhibit systemic manifestations.
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Imamura et al. (2013) conducted an observational in Pediatric pneumonia (n=28). Enterovirus 68 infection was evaluated on Detection of EV68 in serum. Enterovirus 68 was detected in the serum of 12 (43%) of 28 pediatric pneumonia patients with EV68-positive nasopharyngeal specimens, suggesting the virus can cause viremia.
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