Sox17 and Coronary Arteriogenesis in Development

oronary artery disease causes acute myocardial infarction, making it one of the leading causes of mortality and morbidity worldwide.An acute coronary artery occlusion can result in the death of a substantial number of cardiomyocytes, leading to myocardial infarction and heart failure.The revascularization of ischemic myocardium by promoting new artery generation or collateral artery formation represents a promising therapeutic approach for treating coronary artery disease.Learning from naturally developing coronary arteriogenesis may be an important step toward the goal of therapeutic neovascularization in adults.Therefore, a better understanding of developmental coronary arteriogenesis would provide critical information and novel insights that might be deployed for therapeutic neovascularization of ischemic myocardium in the future.However, we still do not fully understand how coronary arteries are generated in development and what molecular mechanisms regulate their formation and specification.