Conditions for the preparation of microcapsules containing asparaginase by interfacial polymerization were investigated. The activity of microcapsules prepared under the optimal conditions was about 37% compared with that of native asparaginase. Particle size of microcapsules could be controlled by determining the stirring rate and concentration of Span 85. The membranes of microcapsules were resistant to mechanical shock or attack of chymotrypsin, and no leakage of asparaginase from microcapsules was observed.
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Mori et al. (1972) studied this question.
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