Key result
Activation of pulmonary C fibers causes severe respiratory discomfort but does not impair limb motoneuron output to voluntary, reflex, or locomotor drives in awake humans.
Why the study?
Does activation of pulmonary C fibers impair the output of limb motoneurons in awake humans?
Does activation of pulmonary C fibers impair the output of limb motoneurons in awake humans?
Contrary to animal models, activation of pulmonary C fibers does not inhibit limb motoneuron output during exercise in awake humans.
Answers are grounded in this paper and cite their sources.
Challenges animal-to-human translation of pulmonary C-fiber effects; leaves open their contribution to exercise limitation in cardiopulmonary disease.
In animals, the J reflex evoked by pulmonary C fibers provides potent inhibition of limb muscles and would act to limit exercise. However, recent work shows that although activation of these fibers causes severe respiratory discomfort, it does not impair the output of limb motoneurons to voluntary, reflex, or locomotor drives in awake humans.
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Gandevia et al. (2000) studied this question. Activation of pulmonary C fibers causes severe respiratory discomfort but does not impair limb motoneuron output to voluntary, reflex, or locomotor drives in awake humans.
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