Key result
Obesity in nulliparous women was associated with a 9.2% rate of preeclampsia compared to 3.4% in women with normal BMI, with distinct early pregnancy risk factors identified for each group.
Why the study?
What are the clinical and biomarker risk factors for preeclampsia in nulliparous women with obesity compared to those with a normal BMI?
Cohort (n=3,940)
What are the clinical and biomarker risk factors for preeclampsia in nulliparous women with obesity compared to those with a normal BMI?
Women with obesity and those with a normal BMI have different early pregnancy clinical and biomarker risk factors for developing preeclampsia.
Answers are grounded in this paper and cite their sources.
Supports BMI-specific preeclampsia risk assessment in nulliparous women; hypothesis-generating for tailored prevention trials.
OBJECTIVE: ). METHODS: In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity. RESULTS: Among 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective. CONCLUSIONS: Women with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia.
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Vieira et al. (2016) conducted a cohort in Preeclampsia (n=3,940). Obesity vs. Normal BMI was evaluated on Development of preeclampsia. Obesity in nulliparous women was associated with a 9.2% rate of preeclampsia compared to 3.4% in women with normal BMI, with distinct early pregnancy risk factors identified for each group.
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