Key result
Exercise training increased spontaneous aortic depressor nerve sensitivity toward normal levels in rats with ischemia-induced heart failure (1,791 vs 1,150 au/mmHg; P=0.05).
Why the study?
Does exercise training improve afferent aortic depressor nerve activity sensitivity in rats with ischemia-induced heart failure?
Population
29 rats (20 with ischemia-induced heart failure, 9 normal controls)
Comparison
Exercise training vs Untrained HF rats and normal control rats
Design
Preclinical
Authors
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May support baroreflex restoration via nerve sensitization in rodent HF; leaves open human translation.
Does exercise training improve afferent aortic depressor nerve activity sensitivity in rats with ischemia-induced heart failure?
Absolute Event Rate: 1791% vs 1150%
p-value: p=0.05
Exercise training improves aortic depressor nerve sensitivity in rats with ischemia-induced heart failure, providing a mechanism for the amelioration of baroreflex control.
Rondon et al. (2006) studied Ischemia-induced heart failure (n=29). Exercise training vs. Untrained was evaluated on Spontaneous afferent aortic depressor nerve activity (AODN) sensitivity (p=0.05). Exercise training increased spontaneous aortic depressor nerve sensitivity toward normal levels in rats with ischemia-induced heart failure (1,791 vs 1,150 au/mmHg; P=0.05).
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