Key result
Body adiposity index (BAI) showed a stronger correlation with endothelium-dependent vasodilation (r = -0.51, P<0.0001) than z-BMI or waist circumference, especially in females.
Why the study?
Does body adiposity index (BAI) correlate better with emerging cardiovascular risk markers than z-BMI or waist circumference in adolescents?
Cross-Sectional (n=40)
Does body adiposity index (BAI) correlate better with emerging cardiovascular risk markers than z-BMI or waist circumference in adolescents?
The body adiposity index (BAI) correlates more strongly with endothelium-dependent vasodilation than z-BMI or waist circumference in adolescents, suggesting it may be a superior anthropometric marker for emerging cardiovascular risk.
Answers are grounded in this paper and cite their sources.
BAI may better identify endothelial dysfunction than z-BMI or waist circumference in adolescents; hypothesis-generating and requires prospective validation before clinical adoption.
OBJECTIVE: The body adiposity index (BAI) has been recently proposed as an alternative index to body mass index (BMI) and waist circumference (WC) to evaluate adiposity in adults, with special focus on its ability to discriminate gender specificities on adiposity. Endothelial dysfunction, circulating endothelial cells (CECs), endothelin-1 and adipocytokines are all related to atherosclerosis and nowadays considered as markers of emerging cardiovascular (CV) risk. This study aimed to determine in normal weight and obese adolescents which measures of body composition (BAI and z-BMI) or distribution (WC) correlate better with emerging CV risk markers. PATIENTS: Forty adolescents were selected according to BMI: normal weight (n = 20; 7 girls/13 boys, 14·7 ± 1·4 years, 53·4 ± 6·0 kg, z-BMI 0·6 ± 0·1) and obese ones (n = 20; 13 girls/7 boys, 14·1± 1·0 years, 86·7 ± 11·5 kg, z-BMI 2·7 ± 0·4). MEASUREMENTS: Body fat and fat mass were measured by dual-energy X-ray absorptiometry (DXA). Non-nutritive skin microvascular reactivity was evaluated by laser Doppler flowmetry with iontophoretic release of vasoactive drugs. Activated CECs were assessed by flow cytometric analysis. RESULTS: In adolescents, the measurement of % fat by DXA showed high correlation with BAI (ρ = 0·75, P < 0·0001), z-BMI (r = 0·84, P < 0·0001) and WC (r = 0·83, P < 0·0001). Endothelin-1 and activated CECs did not correlate with any anthropometric measures while adipocytokines expressed variable associations among them. Endothelium-dependent vasodilation showed higher correlation with BAI (r = -0·51, P < 0·0001) compared to z-BMI (r = -0·40, P < 0·001) or WC (r = -0·45, P < 0·001), specially on females. CONCLUSIONS: BAI was associated with emerging CV risk markers in adolescents but further research is needed to evaluate its potential in clinical and epidemiological sets.
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Dias et al. (2013) conducted a cross-sectional in Obesity and cardiovascular risk (n=40). Body adiposity index (BAI) vs. z-BMI and waist circumference was evaluated on Correlation with endothelium-dependent vasodilation (r = -0.51, p=<0.0001). Body adiposity index (BAI) showed a stronger correlation with endothelium-dependent vasodilation (r = -0.51, P<0.0001) than z-BMI or waist circumference, especially in females.
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