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January 1, 1989British Journal of PharmacologyOpen Access

The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs

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Why the study?

Does GR43175 affect carotid arterial blood flow and vascular resistance in barbitone-anaesthetized dogs?

Population

Barbitone-anaesthetized dogs

Design

Preclinical

Authors

WFW. FeniukUniversity of CambridgePHP.P.A. HumphreyUniversity of CambridgeMPM.J. PerrenGlaxoSmithKline (United Kingdom)

Discussion

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Overview

GR43175 supports carotid vasoconstriction via 5-HT1-like receptors in dogs; leaves open translation to human migraine therapy.

Structured PICO

Does GR43175 affect carotid arterial blood flow and vascular resistance in barbitone-anaesthetized dogs?

P
Population
Barbitone-anaesthetized dogs
I
Intervention
GR43175 (1-1000 micrograms kg-1, i.v.)
O
Outcome
Carotid arterial blood flow and vascular resistancesurrogate

GR43175 produces selective vasoconstriction in the carotid arterial circulation of anaesthetized dogs via activation of 5-HT1-like receptors.

Cite This Study

Feniuk et al. (1989) studied this question.

synapsesocial.com/papers/6a947473beb4e1ebf564d490https://doi.org/10.1111/j.1476-5381.1989.tb11787.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GR43175, a selective agonist for the 5‐HT1‐like receptor in dog isolated saphenous vein1988 · 301 citations
  2. 2MODIFICATION OF THE VASOMOTOR ACTIONS OF METHYSERGIDE IN THE FEMORAL ARTERIAL BED OF THE ANAESTHETIZED DOG BY CHANGES IN SYMPATHETIC NERVE ACTIVITY1981 · 26 citations
  3. 3Ergotamine-Induced Constriction of Cranial Arteriovenous Anastomoses in Dogs Pretreated with Phentolamine and Pizotifen1983 · 28 citations
  4. 4EVIDENCE FOR TWO TYPES OF EXCITATORY RECEPTOR FOR 5‐HYDROXYTRYPTAMINE IN DOG ISOLATED VASCULATURE1980 · 136 citations