Key result
Paroxysmal vagal overactivity in infants is reviewed regarding its clinical diagnosis, familial aspects, potential link to sudden infant death syndrome, and treatment considerations.
This review highlights paroxysmal vagal overactivity as a potential risk factor for apparent life-threatening events and sudden infant death syndrome, discussing its diagnosis and management.
May support ALTE evaluation in infants; hypothesis-generating for SIDS link and management, needing prospective validation.
The possibility of reversible cardiac asystoly due to paroxysmal vagal overactivity (VO) has been well studied, first in adults, then in children, and finally in breath-holding spells. Few studies deal with infants and the incidence of VO among preterm, apparent life-threatening event (ALTE) and sudden infant death syndrome (SIDS). In this review, we summarize data acquired during the past 20 years leading to the diagnosis of VO in infants. We describe the clinical aspects of VO in infants and young children such as Holter-ECG and oculocardiac reflex criteria. The familial aspect of VO and its possible link with SIDS (a new risk factor?) are discussed. Finally, whether or not to treat infants with symptomatic VO is discussed.
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Lucet et al. (2000) conducted a review in Paroxysmal vagal overactivity, apparent life-threatening event, sudden infant death syndrome. Paroxysmal vagal overactivity was evaluated. Paroxysmal vagal overactivity in infants is reviewed regarding its clinical diagnosis, familial aspects, potential link to sudden infant death syndrome, and treatment considerations.
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