Key result
Etoposide therapy induced a myocardial infarction in a child with haemophagocytic lymphohistiocytosis, which resolved following drug discontinuation and supportive measures.
Etoposide administration may be associated with myocardial infarction in pediatric patients, which can resolve upon drug discontinuation and supportive care.
Etoposide may be linked to reversible MI in pediatric HLH; hypothesis-generating and should not yet change practice.
We report a male child with haemophagocytic lymphohistiocytosis who developed myocardial infarction after receiving etoposide. He recovered well with supportive measures and after discontinuation of etoposide. We discuss the possible mechanisms and differential diagnoses of myocardial infarction in our patient.
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Escoto et al. (2010) studied this question. Etoposide therapy induced a myocardial infarction in a child with haemophagocytic lymphohistiocytosis, which resolved following drug discontinuation and supportive measures.
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