Key result
Acute milrinone administration did not cause significant changes in platelet number or function compared to no milrinone in patients undergoing cardiac operations requiring CPB.
Why the study?
Does milrinone affect platelet number and function in patients undergoing cardiac surgery requiring cardiopulmonary bypass?
Population
27 patients undergoing cardiac surgery requiring cardiopulmonary bypass (CPB)
Comparison
Milrinone at a loading dose of 50-75… vs No milrinone
Design
RCT, randomized
Follow-up
24 hours after CPB
Authors
Loading...
Supports milrinone use without added platelet caution in CPB surgery; confirms neutral effect in RCT.
RCT (n=27)
Randomized
Does milrinone affect platelet number and function in patients undergoing cardiac surgery requiring cardiopulmonary bypass?
Milrinone does not appear to induce significant acute thrombocytopenia or platelet dysfunction beyond the baseline effects of cardiopulmonary bypass in cardiac surgery patients.
Kikura et al. (1995) conducted an RCT in Cardiac surgery requiring cardiopulmonary bypass (n=27). Milrinone vs. No milrinone was evaluated on Platelet number and function. Acute milrinone administration did not cause significant changes in platelet number or function compared to no milrinone in patients undergoing cardiac operations requiring CPB.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: