Why the study?
How does cardiopulmonary bypass affect hemostasis parameters in patients undergoing open heart surgery?
Population
63 patients undergoing cardiopulmonary bypass for open heart surgery.
Design
Cohort
Follow-up
48 hours postoperatively
Authors
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Marked clotting factor/platelet declines during CPB rarely reach critical thresholds; hypothesis-generating for transfusion thresholds, needs prospective trials.
How does cardiopulmonary bypass affect hemostasis parameters in patients undergoing open heart surgery?
Cardiopulmonary bypass induces significant but generally non-critical decreases in clotting factors and platelet function, which largely recover by 48 hours postoperatively.
Mammen et al. (1985) studied this question.
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