MANNITOL is the reduced form of the 6-carbon sugar mannose. It is a time-honored osmotic diuretic for research purposes, but has received only sporadic and limited clinical attention.1 2 3 4 5 Urea and other clinically popular osmotic diuretics are composed of small particles that are freely filtered across the glomerulus into the lumen of the renal tubule.6 Urinary excretion of the particles, with their obligatory water, constitutes an osmotic diuresis. The diuretic effectiveness of urea and similar agents per mol administered is limited by their rapid diffusion from the blood stream into the extravascular fluids and their reabsorption from the tubular lumen of . . .
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Barry et al. (1961) studied this question.
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