Vox Sanguinis (2009) 96, 62-85 IVIG therapy in contrast to the usual 10-20 exchange transfusions per year.However, the infants later needed top-up RBC transfusion that renders the reduction of donor exposure by IVIG therapy doubtful.In the Netherlands, a clinical trial is being conducted to compare the effect of highdose IVIG and placebo on the number of exchange and top-up transfusions.
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New et al. (2008) studied this question.