Key result
TNF-α plays a dual role in the cardiovascular system, acting beneficially at low physiological concentrations but serving as a major mediator of inflammation and pathology at high chronic levels.
Why the study?
The role of TNF-alpha in the cardiovascular system remains controversial regarding whether its effects are beneficial or harmful.
This review highlights the dual, concentration-dependent role of TNF-α in the cardiovascular system, where it provides physiological cardioprotection at low levels but drives pathological remodeling and heart failure at high levels.
Supports dual TNF-α role in cardiac health and disease; leaves open targeted interventions for validation in trials.
Tumor necrosis factor (TNF- alpha) plays important role in pathophysiology of cardiovascular system and had been comprehensively studied over the last 20 years. These studies demonstrate both Detrimental and potentially conflicting roles of TNF-α in pathophysiology of heart. Beneficial effects of TNF-α includes cardioprotective action against ischemia, myocarditis, pressure overload and preventive action against potential adverse effects including development of atherosclerosis, reperfusion injury, hypertrophy, and heart failure. However, TNF-α is still controversial for its beneficial or harmful effects for cardiovascular system. This review includes evaluation of possible role of TNF-α in cardiovascular system specifically in pathophysiology and morphology of cardiomyocytes. Further this article mainly emphases on the claimed role of TNF-α pathways with concerning essential cardiac cellular processes which may have unswerving adaptive effects in the heart with respect to future research directions.
No takes yet. Share an insight, caveat, or question.
Dhiman et al. (2021) conducted a review in Cardiovascular diseases. Tumor necrosis factor-alpha (TNF-α) was evaluated. TNF-α plays a dual role in the cardiovascular system, acting beneficially at low physiological concentrations but serving as a major mediator of inflammation and pathology at high chronic levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: