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December 16, 2014PLoS ONEOpen Access

The Shared Crosstalk of Multiple Pathways Involved in the Inflammation between Rheumatoid Arthritis and Coronary Artery Disease Based on a Digital Gene Expression Profile

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Key result

Transcriptome analysis identified 213 differentially expressed genes in rheumatoid arthritis and 152 in coronary artery disease compared to healthy controls, with 73 shared genes highlighting common inflammatory pathways such as IL-8 signaling.

Population

30 female participants recruited at China-Japan Friendship Hospital in Beijing.

Comparison

Digital gene expression profiling of peripheral… vs Healthy normal controls.

Design

Cross-sectional

Authors

XNXuyan NiuCLCheng LüCXCheng Xiao

Discussion

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Overview

Shared DEGs suggest potential dual targets in RA and CAD; hypothesis-generating and requires prospective validation before any clinical consideration.

Study Design

Type

Cross-Sectional (n=30)

Multicenter

No

Structured PICO

P
Population
30 female participants, comprising 10 with active rheumatoid arthritis, 10 with coronary artery disease, and 10 healthy controls, underwent digital gene expression profiling of peripheral blood mononuclear cells.
E
Exposure
Digital gene expression profiling of peripheral blood mononuclear cells (transcriptome analysis).
C
Comparator
Healthy normal controls.
O
Outcome
Differentially expressed genes (DEGs) and shared canonical pathways/networks between RA and CAD.surrogate

Main Result

p-value: p=<0.01

Transcriptome analysis reveals shared inflammatory genetic pathways (IL-8, antigen presentation, OX40, TREM1) between rheumatoid arthritis and coronary artery disease, providing potential targets for simultaneous treatment.

Limitations

  • Small sample size of only 10 patients per group
  • Study restricted to female patients only, limiting generalizability to males

Cite This Study

Niu et al. (2014) conducted a cross-sectional in Rheumatoid Arthritis and Coronary Artery Disease (n=30). Rheumatoid arthritis and coronary artery disease vs. Healthy controls was evaluated on Differentially expressed genes (DEGs) compared to normal controls (p=<0.01). Transcriptome analysis identified 213 differentially expressed genes in rheumatoid arthritis and 152 in coronary artery disease compared to healthy controls, with 73 shared genes highlighting common inflammatory pathways such as IL-8 signaling.

synapsesocial.com/papers/6a9479457779db04076e5bd4https://doi.org/10.1371/journal.pone.0113659
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  5. 5Elucidation of hub cross-talk genes as potential biomarkers and drug prediction for chronic periodontitis and rheumatoid arthritis: A bioinformatics analysis2025