Key result
Pulsatile flow in intracranial aneurysms can experience hydrodynamic instability during the decelerating systolic phase, causing high-frequency oscillations of 20-50 Hz and significant fluctuations in wall shear stress.
Population
3 patient-specific internal carotid artery models with aneurysms
Design
Preclinical
Authors
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Hypothesis-generating for flow instability in aneurysm remodeling; human validation required before any clinical consideration.
High-resolution CFD simulations reveal that aneurysmal flow can become unstable during decelerating systole, causing high-frequency oscillations in wall shear stress that may contribute to aneurysm remodeling and rupture.
Baek et al. (2009) studied Intracranial aneurysms (n=3). Pulsatile blood flow (CFD simulation) was evaluated on Flow instability and wall shear stress variation. Pulsatile flow in intracranial aneurysms can experience hydrodynamic instability during the decelerating systolic phase, causing high-frequency oscillations of 20-50 Hz and significant fluctuations in wall shear stress.
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