Key result
Open heart surgery successfully extracted a large right atrial thrombus transiting a patent foramen ovale in a 44-year-old woman with the Prothrombin G2021 mutation.
Why the study?
The Prothrombin mutation G2021 alone is considered a minor risk factor for thromboembolism, but thromboembolic events are more likely in the presence of additional risk factors.
Case Report (n=1)
This case highlights the risk of severe thromboembolic events, such as a transiting atrial thrombus causing pulmonary embolism, in patients with a patent foramen ovale and Prothrombin G2021 mutation.
Supports permanent anticoagulation in PFO with prothrombin G2021 mutation post-embolism; leaves open optimal strategies from larger studies.
The Prothrombin mutation G2021 alone is considered a minor risk factor for thromboembolism, but thromboembolic events are more likely in the presence of additional risk factors. We report on a 44-year-old female with an atrial thrombus causing pulmonary embolism and transiting through a patent foramen ovale. The thrombus was extracted by open heart operation. The patient had a family history for thromboembolic events. Further diagnostic after surgery found the patient positive for the Prothrombin mutation G2021, but not for the Factor V Leiden mutation. After surgery, a permanent oral anticoagulation has been started.
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Anderson et al. (2021) conducted a case report in Atrial thrombus with pulmonary embolism and patent foramen ovale (n=1). Open heart operation was evaluated. Open heart surgery successfully extracted a large right atrial thrombus transiting a patent foramen ovale in a 44-year-old woman with the Prothrombin G2021 mutation.
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