Key result
Higher early SS-MIBG values assessed with a CZT camera clustered with more elevated summed rest score (P=0.023) and impaired ejection fraction (P=0.027).
Why the study?
Does a low-dose imaging protocol with a CZT dedicated camera identify relationships between regional adrenergic innervation heterogeneity, myocardial perfusion, and contractile function in patients with or without ischaemic heart disease?
Cross-Sectional (n=28)
Does a low-dose imaging protocol with a CZT dedicated camera identify relationships between regional adrenergic innervation heterogeneity, myocardial perfusion, and contractile function in patients with or without ischaemic heart disease?
Answers are grounded in this paper and cite their sources.
An altered early SS-MIBG assessed with a low-dose CZT cardiac camera protocol identifies patients with more impaired myocardial perfusion and contractile function.
AIMS: To investigate the relationships between regional adrenergic innervation heterogeneity, myocardial perfusion, and contractile function obtained by means of a low-dose imaging protocol with a cadmium-zinc-telluride (CZT) dedicated camera. METHODS: Twenty-eight patients with or without ischaemic heart disease underwent (123)I-metaiodobenzylguanidine (MIBG) planar scintigraphic and CZT early and delayed evaluations followed by (99m)Tc-tetrofosmin rest gated CZT with a single-day protocol. The heart-to-mediastinum ratio and the washout rate were computed from planar (123)I-MIBG images. The summed (123)I-MIBG defect scores (SS-MIBG) were semi-quantitatively assessed from CZT images. The summed rest score (SRS), summed motion score (SMS), and summed thickening score (STS) were quantitated from (99m)Tc-tetrofosmin images. RESULTS: Sixteen patients showed a depressed left ventricular systolic function [ejection fraction (EF)<50%]. They presented higher SRS (P = 0.007), SMS (P < 0.001), STS (P < 0.001), and early SS-MIBG (P = 0.007) values than those with normal contractile function. Interestingly, higher early SS-MIBG values, index of regional sympathetic innervation heterogeneity, clustered with more elevated SRS (P = 0.023), and more impaired measures of regional and global left ventricle systolic function, i.e. SMS (P = 0.046), STS (P = 0.014), and EF (P = 0.027). At multivariate analysis, a higher SRS (P = 0.039) remained the only independent predictor of more elevated early SS-MIBG values. In the 20 of 28 ischaemic patients, the correlations between early SS-MIBG and SMS (P = 0.017) and also STS (P = 0.036) were further confirmed. The effective dose of the investigation was 4.2 ± 0.72 mSv. CONCLUSIONS: An altered early SS-MIBG, assessed with a low-dose imaging protocol and a CZT cardiac camera, identifies patients with more impaired myocardial perfusion and contractile function.
No takes yet. Share an insight, caveat, or question.
Gimelli et al. (2013) conducted a cross-sectional in Ischaemic heart disease (n=28). Low-dose imaging protocol with a cadmium-zinc-telluride (CZT) dedicated camera was evaluated on Relationship between early SS-MIBG values and myocardial perfusion/contractile function (p=0.039). Higher early SS-MIBG values assessed with a CZT camera clustered with more elevated summed rest score (P=0.023) and impaired ejection fraction (P=0.027).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: