High-speed scanning of planar images showing 123I-MIBG uptake using a whole-body CZT camera: a phantom and clinical study

Figures

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  Fig. 1. Image processing and HMR calculation. a Images with different energy window widths (symmetrical, ± 2.5%, 5.0%, 7.5%, 10%, 20%, and 40%) using a fixed collection time (300 s). b Images with different collection times (25, 50, 100, and 200 s) using a fixed window width (± 5.0%). c The regions of interest (ROIs) manually set on the heart (52.5 cm2, oval-shaped) and mediastinum (10.5 cm2, square-shaped) in the anterior and posterior planar views. d Relationship between energy (x-axis) and radioactive counts (y-axis) and set energy peak ± window widths (vertical white lines)

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  Fig. 2. Changes in parameters at different window widths (phantom study). With the collection time fixed at 300 s, the relationships between different window widths (x-axis) and radioactive counts in the ROIs on the heart (a) and mediastinum (b), HMR (c), and CV of the ROIs on the heart (d), are shown. Blue circles—normal model, anterior view; blue triangles—normal model, posterior view; red circle—disease model, anterior view; red triangle—disease model, posterior view

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  Fig. 3. Changes in parameters at different collection times (phantom study). With the window width fixed at ± 5%, the relationship between different collection times (x-axis) and radioactive counts in the ROIs on the heart (a) and mediastinum (b), HMR (c), are shown. The meanings of the markers are the same as indicated in Fig. 2

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  Fig. 4. Comparison between CZT-based and Anger cameras (phantom study). The relationship between different collection times (x-axis) and radioactive counts in the ROIs on the heart (upper graphs) and mediastinum (middle graphs), and HMR (lower graphs) in the normal (a) and disease (b) models using three types of cameras. Pink circle—CZT-based camera, light blue triangle—Anger cameras with MEGAP collimators, yellow square—Anger cameras with LEUHR collimators

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  Fig. 5. Concordance of early HMRs between different collection times (clinical study). Correlations between the HMRs at early phase with collection times of 300 s (x-axis) and 25 (a), 50 (b), 100 (c), and 200 s (d) are demonstrated. Bland-Altman analyses show the relationship of the mean (x-axis) and difference (y-axis) of two corresponding values. ICC intra-class correlation, LOA limit of agreement

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  Fig. 6. a–d Concordance of delayed HMRs between different collection times (clinical study). Correlations and Bland-Altman analyses on the HMRs at the delayed phase are shown. See details in the legends of Fig. 5