Key result
123I-MIBG imaging parameters correlated closely with 11C-HED PET for assessing cardiac sympathetic innervation (late H/M r=0.84), though 11C-HED PET was better for regional abnormalities.
Why the study?
How do (123)I-MIBG imaging parameters correlate with (11)C-HED PET measures for assessing cardiac sympathetic innervation in patients with left ventricular dysfunction?
Population
21 patients with left ventricular dysfunction (mean left ventricular ejection fraction, 39 ± 15%)
Comparison
I-metaiodobenzylguanidine (I-MIBG) imaging vs C-hydroxyephedrine (C-HED) positron emission…
Design
Cross-sectional
Authors
Loading...
123I-MIBG may estimate global sympathetic innervation in LV dysfunction; leaves open whether it can supplant PET for regional assessment.
Observational (n=21)
How do (123)I-MIBG imaging parameters correlate with (11)C-HED PET measures for assessing cardiac sympathetic innervation in patients with left ventricular dysfunction?
Effect estimate: r=0.84
(123)I-MIBG H/M ratio reliably estimates global cardiac sympathetic innervation compared to (11)C-HED PET, but PET is superior for assessing regional abnormalities.
Matsunari et al. (2010) conducted an observational in Left Ventricular Dysfunction (n=21). 123I-MIBG imaging vs. 11C-HED PET was evaluated on Correlation between late 123I-MIBG heart-to-mediastinum ratio and 11C-HED retention (r=0.84). 123I-MIBG imaging parameters correlated closely with 11C-HED PET for assessing cardiac sympathetic innervation (late H/M r=0.84), though 11C-HED PET was better for regional abnormalities.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: