Why the study?
Does pulmonary hypertension alter left ventricular sympathetic neuronal function as measured by 123I-MIBG imaging in patients with chronic lung or pulmonary vascular disease?
Observational (n=20)
Does pulmonary hypertension alter left ventricular sympathetic neuronal function as measured by 123I-MIBG imaging in patients with chronic lung or pulmonary vascular disease?
Answers are grounded in this paper and cite their sources.
Pulmonary hypertension is associated with left heart sympathetic neuronal dysfunction that appears to initially affect the interventricular septum before involving the left ventricular free wall.
Iodine-123-metaiodobenzylguanidine [123I-MIBG] has been used to evaluate the cardiac sympathetic nervous system. We evaluated the effect of pulmonary hypertension on the sympathetic neuronal function of the left ventricle in patients with pulmonary hypertension. We studied 20 patients with either chronic lung disease or pulmonary vascular disease. The patients were divided into a pulmonary hypertensive group and a control group. Single photon emission tomography was performed in the resting state 15 min and 4 h after administration of 123I-MIBG. Regions of interest (ROI) were set in the left ventricular (LV) free wall, the interventricular septum (IVS) and outside the LV free wall on short-axis images. The washout rate and the ROI/LV uptake ratio were calculated in each ROI. The IVS:LV uptake ratio was significantly lower in the pulmonary hypertensive group than in the control group. Our results suggest that left heart sympathetic neuronal dysfunction initially occurs in the IVS before it involves the LV free wall subsequently.
No takes yet. Share an insight, caveat, or question.
Morimitsu et al. (1997) conducted an observational in Pulmonary hypertension (n=20). Pulmonary hypertension vs. Control group was evaluated on Interventricular septum to left ventricular (IVS:LV) 123I-MIBG uptake ratio.
Synapse has enriched 10 related papers. Consider them for comparative context: