Key result
The degree of myocardial fibrosis estimated by baseline LGE-CMR imaging (LGE area), but not by endomyocardial biopsy, independently predicted left ventricular reverse remodeling (β = 0.44, p<0.001) in patients with newly diagnosed idiopathic dilated cardiomyopathy.
Why the study?
Does baseline LGE-CMR imaging predict left ventricular reverse remodeling and prognosis better than baseline endomyocardial biopsy in patients with newly diagnosed idiopathic dilated cardiomyopathy?
Cohort (n=75)
Blinded observers for LGE and EMB
No
Does baseline LGE-CMR imaging predict left ventricular reverse remodeling and prognosis better than baseline endomyocardial biopsy in patients with newly diagnosed idiopathic dilated cardiomyopathy?
Effect estimate: β = 0.44 (95% CI 0.87-2.53)
p-value: p=<0.001
Baseline LGE-CMR imaging is superior to endomyocardial biopsy for predicting left ventricular reverse remodeling and cardiac event-free survival in patients with newly diagnosed idiopathic dilated cardiomyopathy.
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LGE-CMR may refine prognostic stratification in new idiopathic DCM; extends imaging data but leaves biopsy utility open pending validation.
Nabeta et al. (2013) conducted a cohort in Idiopathic dilated cardiomyopathy (n=75). Late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) imaging vs. Endomyocardial biopsy (EMB) was evaluated on Change in left ventricular end-systolic volume index (LVESVI) at 1 year (left ventricular reverse remodeling) (β = 0.44, 95% CI 0.87-2.53, p=<0.001). The degree of myocardial fibrosis estimated by baseline LGE-CMR imaging (LGE area), but not by endomyocardial biopsy, independently predicted left ventricular reverse remodeling (β = 0.44, p<0.001) in patients with newly diagnosed idiopathic dilated cardiomyopathy.
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