Key result
Long-term sequential treatment with the angiogenesis inhibitors sorafenib and axitinib for metastatic renal cell carcinoma was associated with the coincidental emergence of aortic dissection and cardiac dysfunction.
Population
1 66-year-old man with metastatic renal cell carcinoma post-nephrectomy, with no prior coronary risk factors.
Design
Case_report
Follow-up
6 years
Authors
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May warrant closer cardiovascular monitoring on prolonged VEGF inhibitors; leaves open any causal link to aortic dissection.
Case Report (n=1)
Long-term use of VEGF inhibitors such as sorafenib and axitinib may be associated with the coincidental development of aortic dissection and cardiac dysfunction, highlighting the need for careful cardiovascular monitoring in oncology patients.
Takada et al. (2018) conducted a case report in Metastatic Renal Cell Carcinoma (n=1). Sorafenib and axitinib was evaluated on Development of aortic dissection and cardiac dysfunction. Long-term sequential treatment with the angiogenesis inhibitors sorafenib and axitinib for metastatic renal cell carcinoma was associated with the coincidental emergence of aortic dissection and cardiac dysfunction.
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