Why the study?
Does propranolol with or without anticonvulsants prevent arrhythmias and syncopal attacks in patients with Romano-Ward syndrome?
Does propranolol with or without anticonvulsants prevent arrhythmias and syncopal attacks in patients with Romano-Ward syndrome?
Propranolol, either alone or in combination with diphenylhydantoin and phenobarbital, may effectively prevent life-threatening arrhythmias and syncopal attacks in patients with Romano-Ward syndrome.
Propranolol may prevent recurrent syncope in Romano-Ward syndrome; leaves open need for controlled trials.
This paper deals with 2 female cases, aged 21 and 17, diagnosed as the Romano-Ward syndrome. They belonged to different families. Both showed autosomal dominant inheritant traits. From their traits one case (Case 1) was suspected as being in the heterozygous state, while the other (Case 2) in the homozygous. The severity in clinical symptoms did not differ from each other. By studying our cases and the literature so far published, the combined use of propranolol, diphenylhydantoin, and phenobarbital was inferred to act effectively for the prevention of arrhythmias seen in the present syndrome.
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Hanazono et al. (1973) studied this question.
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