Answers are grounded in this paper and cite their sources.
(1R,2R)-1-Phenyl-1-alkyl/arylamino-2-(N-alkylamino)propane hydrochloride salts have been synthesized with high degree of enantiomeric purity from (1S,2R)-(+)-1-phenyl-2-(N-alkylamino)-1-propanol through the corresponding chloro derivatives. This reaction sequence involves three inversions with overall inversion of configuration at C-1.
No takes yet. Share an insight, caveat, or question.
Kumar et al. (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: