Key result
Cardiac ultrasound screening of 34,071 fetuses revealed an overall congenital heart disease incidence of 1.5%, which significantly increased from 1.1% in 2006 to 2.4% in 2009 (P<0.05).
Why the study?
What is the incidence and outcome of congenital heart disease detected by pre- and postnatal screening in a Chinese hospital?
Observational (n=34,071)
No
What is the incidence and outcome of congenital heart disease detected by pre- and postnatal screening in a Chinese hospital?
p-value: p=<0.05
The incidence of fetal CHD in a Chinese hospital was 1.5%, with high mortality before 28 days, highlighting the need for improved prenatal intervention and care.
Rising fetal CHD incidence may warrant enhanced surveillance; leaves open whether trends reflect true increases or detection changes.
BACKGROUND: The pre- and postnatal detection rate, incidence, clinical characteristics and outcomes of congenital heart disease (CHD) have been studied in developed countries for many years, but rarely have large-scale studies been reported in Chinese populations. The aim of the present study was to investigate the pre- and postnatal detection rates, incidence, clinical characteristics and outcomes of CHD in a Chinese hospital in order to improve the future screening and treatment of CHD. METHODS: Fetuses without risk factors for CHD were screened using basic cardiac ultrasound examination (BCUE). Fetuses with suspected cardiac malformation revealed by BCUE and fetuses with risk factors were screened using extended cardiac ultrasound examination. Outcomes recorded from fetal, neonatal and postmortem records over 4 years (2006-2009) included: therapeutic termination of pregnancy, spontaneous abortions or stillbirths, deaths at birth or in the neonatal period (before 28 days of age), and rate of birth and clinical characteristics of newborns. RESULTS: A total of 34,071 fetuses were screened for CHD during a period of 4 years, of which 173 fetuses were screened for CHD using BCUE and 301 fetuses were screened using extended cardiac ultrasound examination. The incidence of fetal CHD increased from 1.1% in 2006 to 2.4% in 2009 (P < 0.05), yielding an overall incidence of 1.5% (523/34,071). Of the fetuses with CHD, 48.2% (252/523) died before 28 days of age (including intra-uterine death and termination of pregnancy), 51.8% (271/523) lived more than 28 days and the incidence of live newborns with CHD was 0.80% (271/34071). CONCLUSIONS: The prevalence of CHD was quite common in this Chinese hospital. Detailed profiles of CHD suggest that, while training programs in obstetric screening at this hospital were beneficial, prenatal intervention, treatment and care of fetal CHD were inefficient and should be strengthened in China.
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Yu et al. (2011) conducted an observational in Congenital heart disease (n=34,071). Cardiac ultrasound screening was evaluated on Incidence of fetal congenital heart disease (p=<0.05). Cardiac ultrasound screening of 34,071 fetuses revealed an overall congenital heart disease incidence of 1.5%, which significantly increased from 1.1% in 2006 to 2.4% in 2009 (P<0.05).
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