Key result
Heparin produces no significant net benefit in eventual outcome for patients with acute ischaemic stroke across 16 randomized controlled trials involving over 22,000 patients.
Why the study?
Does heparin improve eventual outcome in patients with acute ischaemic stroke?
Does heparin improve eventual outcome in patients with acute ischaemic stroke?
Evidence from over 22,000 patients across 16 RCTs indicates that heparin provides no significant net benefit in acute ischemic stroke, suggesting its use in this setting should be abandoned.
The use of heparin for acute ischaemic stroke has long been controversial. Although it may have some theoretical benefits in preventing fibrin formation and thrombus propagation, data from 16 randomised controlled trials involving more than 22,000 patients show that heparin produces no significant net benefit in eventual outcome.
No takes yet. Share an insight, caveat, or question.
Graeme J. Hankey (1998) studied this question. Heparin produces no significant net benefit in eventual outcome for patients with acute ischaemic stroke across 16 randomized controlled trials involving over 22,000 patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: