Heparin Flushes and Thrombocytopenia

Letters and Corrections1 July 1986Heparin Flushes and ThrombocytopeniaPETER S. HEEGER, M.D., JAY T. BACKSTROM, M.D.PETER S. HEEGER, M.D., JAY T. BACKSTROM, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-143_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Heparin-induced thrombocytopenia, with or without arterial thrombi, has been described as occurring with full-dose intravenous heparin treatment, as well as low-dose subcutaneous treatment (1, 2). We report a case of heparin-induced thrombocytopenia from heparin flushes (< 500 U/d).A 73-year-old man was admitted for evaluation of anuric renal failure. A diagnosis of antiglomerular basement membrane disease was eventually made by renal biopsy. During the evaluation the patient became thrombocytopenic, with the platelet count decreasing from 541000 to 50 000/mm3over 8 to 10 days. He had no evidence of sepsis, disseminated intravascular coagulation, or thrombotic thrombocytopenic purpura...References1. BABCOCKDUMPERSCHARFMAN RCW. Heparin-induced immune thrombocytopenia. N Engl J Med. 1976;295:237-41. CrossrefMedlineGoogle Scholar2. HRUSHESKY W. Thrombocytopenia induced by low-dose subcutaneous heparin. Lancet. 1977;2:1286. CrossrefMedlineGoogle Scholar3. KELTONSHERIDANBRAINPOWERSTURPIECARTER JDHPAC. Clinical usefulness of testing for a heparin-dependent platelet-aggregating factor in patients with suspected heparin-associated thrombocytopenia. J Lab Clin Med. 1984;103:606-12. MedlineGoogle Scholar4. CINESKAYWINBINATOMASKISCHREIGER DPMAA. Heparin-associated thrombocytopenia. N Engl J Med. 1980;303:788-95. CrossrefMedlineGoogle Scholar5. KINGKELTON DJ. Heparin-associated thrombocytopenia. Ann Intern Med. 1984;100:535-40. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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