Key result
Prolonged cardiopulmonary bypass time (>5 hours) during complex pulmonary artery reconstruction showed poor correlation with the number of postoperative complications (R-squared 0.002) and hospital length of stay (R-squared 0.005).
Why the study?
Complex pulmonary artery reconstructions require longer periods of cardiopulmonary bypass (CPB) than most congenital heart operations to facilitate surgical repair.
Does prolonged cardiopulmonary bypass increase postoperative complications in children undergoing complex pulmonary artery reconstruction?
Does prolonged cardiopulmonary bypass increase postoperative complications in children undergoing complex pulmonary artery reconstruction?
Effect estimate: R-squared 0.002 for complications, R-squared 0.005 for length of stay
Prolonged cardiopulmonary bypass during complex pulmonary artery reconstruction in children does not appear to predispose to adverse outcomes.
Prolonged CPB may not increase complications after pediatric pulmonary artery reconstruction; hypothesis-generating and requires prospective confirmation.
Cardiopulmonary bypass (CPB) is routinely used for performing congenital heart operations. While most congenital heart operations can be performed with bypass times under 2 hours, complex pulmonary artery reconstructions require longer periods of CPB to facilitate the surgical repair. This article is intended to summarize the surgical and perfusion techniques utilized in patients undergoing complex pulmonary artery reconstructions at our institution. The initial portion of this manuscript provides an in-depth description of the surgical techniques employed for pulmonary artery reconstructions. This information is important in order to understand why prolonged CPB is a necessary requirement. The manuscript then provides a detailed description of the perfusion techniques and the modifications to the CPB circuit. Finally, the manuscript provides a summary of data from a clinical study evaluating the application of these techniques in 100 consecutive children undergoing complex pulmonary artery reconstruction. The data from this study demonstrated that there was a poor correlation between duration of CPB and both the number of postoperative complications and hospital length of stay. Major adverse cardiac events occurred in 11 (11%) patients with one hospital mortality. These results suggest that prolonged CPB does not predispose to adverse outcomes in this select population of patients.
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Margetson et al. (2022) conducted a review in Complex pulmonary artery reconstruction (n=100). Prolonged cardiopulmonary bypass (>5 hours) was evaluated on Correlation between duration of cardiopulmonary bypass and both the number of postoperative complications and hospital length of stay (R-squared 0.002 for complications, R-squared 0.005 for length of stay). Prolonged cardiopulmonary bypass time (>5 hours) during complex pulmonary artery reconstruction showed poor correlation with the number of postoperative complications (R-squared 0.002) and hospital length of stay (R-squared 0.005).
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