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Complanadines A and B (1 and 2, Figure 1) are dimeric Lycopodium alkaloids in the lycodine family that possess significant activity for nerve growth factor (NGF) production from human glial cells.i, ii As such, 1 and 2 are of interest as potential small molecule leads for the treatment of neurodegenerative diseases such as Alzheimer’s disease as well as adjuvants for the regeneration of nerve cells in, for example, spinal cord injury treatment.iii
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Fischer et al. (2013) studied this question.
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