The photoredox-catalyzed α-aminoalkylcarboxylation of aryl allenes with CO 2 and N, N -dimethylanilines is reported for the first time (26 examples, up to 96% yield). In the case of electron-deficient allenes, good regioselectivity was observed (up to 94:6), exclusively generating kinetic products over thermodynamic products. This protocol is a novel synthetic method for highly functionalized β,γ-unsaturated γ-aminobutyric esters.
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Hahm et al. (2021) studied this question.
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