[reaction: see text]. A diastereoselective approach to the synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkylazetidines, including BOC-protected 4-trifluoromethylazetidin-2-ylcarboxylic acid, was developed via Wittig reaction of 4-trifluomethylated beta-lactam followed by alkylation and hydrogenation.
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Jiang et al. (2003) studied this question.
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