First Stereoselective Synthesis of cis 3-CF3-Aziridine-2-carboxylates. A Route to New (Trifluoromethyl) α-Functionalised β-Amino Acids

All articles of this category In the presence of a catalytic amount of BF 3 · Et 2 O, ethyl diazoacetate reacts with CF 3 -imines to afford smoothly the corresponding cis CF 3 -aziridine-2-carboxylates in high yields and with high diastereoselectivity. These CF 3 -aziridines are good precursors of β -amino acids. fluorine - imines - diazo compounds - aziridines - amino acids