The First Synthesis of the Bis(indole) Marine Alkaloid Caulersin

All articles of this category The first synthesis (seven steps) of the bis(indole) marine alkaloid caulersin is described. Construction of the central seven-membered ring is based on a Michael-type addition of the appropriate 2,3′-bis(indolyl)ketone to methylvinylketone followed by intramolecular nucleophilic substitution of the resulting 3-oxoalkylated product. caulersin - marine alkaloid - bis(indole) - bis(indolyl)ketone - nitrene insertion