Key result
A DNA prime followed by protein boost strategy significantly enhanced specific and neutralizing antibodies against FMDV compared to single vaccine modalities in mice and cattle.
Why the study?
Does a DNA prime followed by protein boost enhance immunity against FMDV in mice and cattle?
Does a DNA prime followed by protein boost enhance immunity against FMDV in mice and cattle?
A DNA prime followed by protein boost strategy significantly improves effective immunity and may provide longer protection against FMDV infection in animal models.
Prime-boost strategy has been exhibited its potency to enhance immune responses, which would be important to the success to develop a vaccine against the foot-and-mouth disease virus (FMDV). An eukaryotic expression construct encoding the FMDV capsid VP1 protein with a recombinant VP1 protein or a commercial FMDV vaccine were tested in the prime-boost strategy in mice and cattle trials. The levels of induced specific antibodies, T cell proliferations, and DTH activities were significantly higher in the prime-boost groups than in those vaccinated with DNA, protein or FMDV vaccine alone. More importantly, the levels of neutralizing antibodies in the former groups were significantly higher than others and could last for at least four months in cattle trials. This study suggests that the prime-boost strategy significantly improves the effective immunity and may provide a longer protection against FMDV infection.
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Jin et al. (2005) studied Foot-and-mouth disease virus (FMDV) infection. DNA prime followed by protein boost vs. DNA, protein or FMDV vaccine alone was evaluated on Levels of induced specific antibodies, T cell proliferations, DTH activities, and neutralizing antibodies. A DNA prime followed by protein boost strategy significantly enhanced specific and neutralizing antibodies against FMDV compared to single vaccine modalities in mice and cattle.
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