Chiral synthesis of lignan lactones, (–)-hinokinin, (–)-deoxypodorhizone, (–)-isohibalactone and (–)-savinin, has been achieved by employing an enantioselective deprotonation of 3-(3,4-methylenedioxybenzyl)cyclobutanone with lithium (S, S′)-α,α′-dimethyldibenzylamide, as a key step.
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Honda et al. (1994) studied this question.
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