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Trifluoromethylation of indoles has been performed successfully at room temperature by using a novel palladium-catalyzed oxidation strategy. In this reaction, PhI(OAc)2 has been used as an oxidant and TMSCF3 as a trifluoromethylation reagent (see scheme). A palladium(II/IV) mechanism has been proposed for the formation of the aryl CCF3 bond.
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Mu et al. (2011) studied this question.
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