Synthesis of γ-Lactams by Intermolecular (3 + 2) Annulation of Siloxy Alkynes and 3-Aminooxetanes

This is the authors' abstract. We don't add key points for this paper.

A silver-catalyzed intermolecular (3 + 2) annulation of siloxy alkynes and 3-aminooxetanes has been developed. This process provides mild and convenient access to useful γ-butyrolactams with high regio- and stereoselectivity. Mechanistically, intermolecular C-N bond formation likely precedes oxetane ring opening.