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The unique structural features of the cytotoxic marine macrolide (−)-amphidinolide E make it an intriguing synthetic target. Its total synthesis has now been completed by employing a radical cyclization of a β-alkoxy acrylate to form the oxolane ring, a Kocienski–Julia olefination to create the E CC bond, and a lactonization reaction to close the macrocyclic ring.
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Kim et al. (2006) studied this question.
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