Synthetic study demonstrates C–H functionalization in saturated azaheterocycles using a redox-active protecting group, suggesting efficient routes to diverse nitrogen-containing molecules.
Herein, we report a photocatalytic strategy for the C−H functionalization of saturated azaheterocycles under mild conditions with only one equivalent of starting material. Our strategy is based on a redox active benzamide protecting group that is activated via a halogen‐atom transfer (XAT) process to trigger the formation of an α‐amino radical. This nucleophilic radical intermediate was then engaged in Giese additions and radical cross couplings to afford C−H alkylated and arylated products.
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Pizzio et al. (2023) studied this question.
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