Site‐Isolated Base‐ and Acid‐Mediated Michael‐Initiated Cyclization Cascades

One thing leads to another: Site-isolated base and acid catalysts have been exploited in Michael addition, N-acyl iminium ion cyclization cascades with amide pronucleophiles and α,β-unsaturated carbonyl compounds. The reaction sequence has broad scope, uses commercially available catalysts, is atom efficient, and can be scaled by way of a flow-reactor setup.