An improved method is presented for preparing optically active cyanohydrins in high yield and high enantioselectivity, using R-oxynitrilase from almonds as the catalyst in a biphasic water-organic solvent system. Reaction conditions for two representative substates have been studied with respect to conversion, optical purity and enzyme stability.The suitability of the procedure for industrial use was substantiated by the possibility of reusing the enzyme-containing aqueous phase for the synthesis of R-mandelonitrile.
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Loos et al. (1995) studied this question.
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