Key result
Genetic fate mapping demonstrated that noncardiomyocyte to cardiomyocyte conversion peaks at E8.0-E8.5, ceases by E11.5, and does not contribute to neonatal heart regeneration.
Why the study?
The cellular dynamics of nonmyocyte to cardiomyocyte conversion, the timing of lineage segregation during development, and whether nonmyocytes contribute to neonatal heart regeneration remained unclear.
Population
Embryonic and neonatal hearts
Comparison
Homeostasis vs injury in neonatal hearts
Design
Dual genetic lineage tracing study using 2 orthogonal recombination systems
Authors
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Does not support nonmyocyte targeting for neonatal regeneration; confirms early lineage segregation and leaves open alternative mechanisms.
Lineage segregation between cardiomyocytes and noncardiomyocytes occurs early in embryonic development (between E10.5 and E11.5) and noncardiomyocytes do not contribute to neonatal heart regeneration.
Li et al. (2019) studied Heart development and regeneration. Dual genetic lineage tracing strategy was evaluated on Lineage conversion of noncardiomyocytes to cardiomyocytes. Genetic fate mapping demonstrated that noncardiomyocyte to cardiomyocyte conversion peaks at E8.0-E8.5, ceases by E11.5, and does not contribute to neonatal heart regeneration.
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