Key result
Kv beta 1 interacts with alpha subunits via an alpha4beta_n stoichiometry allowing gradual changes in inactivation, whereas Kv beta 2 self-associates to form oligomers and interacts via an alpha4beta4 stoichiometry.
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Distinct Kv beta stoichiometries may tune cardiac repolarization; leaves open their impact on arrhythmia risk and channel-targeted therapies.
Xu et al. (1998) studied this question. Kv beta 1 and Kv beta 2 subunits was evaluated on Functional stoichiometry of alpha-beta complex. Kv beta 1 interacts with alpha subunits via an alpha4beta_n stoichiometry allowing gradual changes in inactivation, whereas Kv beta 2 self-associates to form oligomers and interacts via an alpha4beta4 stoichiometry.
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