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November 1, 1997

Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes.

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Key result

Kvbeta1 and Kvbeta2 subunits associate and colocalize extensively with Kv1 alpha-subunits, but not Kv2.1, in native adult rat brain tissue.

Authors

KRKenneth J. RhodesBoston UniversityBSBrian W. StrassleBristol-Myers Squibb (United States)MMMichael M. MonaghanTrinity College Dublin

Discussion

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Overview

Does not alter clinical practice; leaves open functional roles of Kv1-beta complexes in human cardiac excitability.

PICO

P
Population
Adult rat brain tissue used to study the association and colocalization of potassium channel subunits.
I
Intervention / Comparator
Subunit-specific antibodies for immunoprecipitation and immunohistochemistry
O
Primary Outcome
Association and colocalization of Kvbeta1 and Kvbeta2 with Kv1 alpha-subunits

Limitations

  • Cannot conclude from comparisons in adjacent sections that individual subunits are precisely colocalized without direct within-section comparisons.

Cite This Study

Rhodes et al. (1997) studied this question. Subunit-specific antibodies for immunoprecipitation and immunohistochemistry was evaluated on Association and colocalization of Kvbeta1 and Kvbeta2 with Kv1 alpha-subunits. Kvbeta1 and Kvbeta2 subunits associate and colocalize extensively with Kv1 alpha-subunits, but not Kv2.1, in native adult rat brain tissue.

synapsesocial.com/papers/6a94d0f12ea3449151e60e15https://doi.org/10.1523/jneurosci.17-21-08246.1997
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective Interaction of Voltage-gated K+ Channel β-Subunits with α-Subunits1996 · 149 citations
  2. 2A Novel K+ Channel β-Subunit (hKvβ1.3) Is Produced via Alternative mRNA Splicing1995 · 135 citations
  3. 3Molecular and functional characterization of a rat brain Kvβ3 potassium channel subunit1995 · 109 citations
  4. 4A Novel β Subunit Increases Rate of Inactivation of Specific Voltage-gated Potassium Channel α Subunits1995 · 170 citations
  5. 5NAB Domain Is Essential for the Subunit Assembly of both α–α and α–β Complexes of Shaker-like Potassium Channels1996 · 145 citations